Anti tumor drugs are a class of drugs used to treat cancer diseases. In recent years, the development of molecular oncology and molecular pharmacology has gradually clarified the essence of tumors; The invention and application of advanced technologies such as large-scale rapid screening, combinatorial chemistry, and genetic engineering have accelerated the process of drug development; The research and development of anti-tumor drugs have entered a new era.
The development strategy of anti-tumor drugs today includes the following points:
(1) targeting solid tumors, which account for over 90% of malignant tumors;
(2) Searching for active ingredients from natural products;
(3) Search for new molecular targets (enzymes, receptors, genes, etc.) targeting the mechanisms of tumor occurrence and development;
(4) High through put screening;
(5) Introduction and application of new technologies: combinatorial chemistry, structural biology, computer-aided design, genetic engineering, DNA chips, pharmacogenomics (combining functional genomics and pharmacology), etc